original dr martens Dr Peter Simpson

dr martens fashion Dr Peter Simpson

Peter holds a BSc Honours degree and a PhD in Molecular Biology from the University of Liverpool in the UK. His first postdoctoral research position was at the Breakthrough Breast Cancer Research Centre at the Institute of London UK. He moved to Australia in 2005 and helped Professor Lakhani establish the Molecular Breast Pathology group. For example, it remains difficult to predict which patients are at risk of their disease returning (recurrence), spreading (metastasis) or which patients will respond to a specific treatment. There has therefore been a concerted effort to supplement the morphological classification of breast disease with molecular parameters that can provide a clearer appreciation for this complexity and better predict tumour behaviour. This ideology has driven significant advancements in the field of molecular pathology research.

Peter’s research program embraces these advances in technology to help better understand mechanisms of disease development and progression and help improve the molecular aspects of diagnosis and patient management.

Invasive Lobular Carcinoma (ILC) are a common special subtype of breast cancer comprising up to 15% of all cases. They exhibit a very characteristic set of clinical, pathological and biological properties, including a progressive decline in survival, an infiltrative pattern of growth and down regulation of cell adhesion molecule, E cadherin. Morphological variants exist that are associated with a worse outcome compared to the classic type. A large component of Peter’s research focuses on aspects of this specific disease subtype, including understanding molecular determinants that predict tumour behaviour, and mechanisms of invasion and metastasis.

Journal Article: Expression of MAGE A and NY ESO 1 cancer testis antigens is enriched in triple negative invasive breast cancers

Raghavendra, Ashwini, Kalita de Croft, Priyakshi, Vargas, Ana Cristina, Smart, Chanel E., Simpson, Peter T., Saunus, Jodi M. and Lakhani, Sunil R. (2018) Expression of MAGE A and NY ESO 1 cancer testis antigens is enriched in triple negative invasive breast cancers.

Journal Article: Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix Trench, Georgia, Al Ejeh, Fares and Lakhani, Sunil R. (2017) Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.

Breast Cancer Research and Treatment,Journal Article:

Fielding, David, Dalley, Andrew J., Bashirzadeh, Farzad, Singh, Mahendra, Nandakumar, Lakshmy, Reed, Amy E. McCart, Black, Debra, Kazakoff, Stephen, Nones, Katia, Pearson, John, Waddell, Nic, Lakhani, Sunil R. and Simpson, Peter T. (2017) .

American Journal of Respiratory and Critical Care Medicine,Extending the strategic importance of the Australian Breast Cancer Tissue Bank to facilitate breast cancer research (NBCF Infrastructure Grant administered by The University of Newcastle)

(2016 2017) University of Newcastle

Defining the genomic and therapeutic landscape of familial breast cancer

(2015 2018) NHMRC Project Grant

Unravelling clinical and molecular heterogeneity in metaplastic breast cancer a unique cell like malignancy (grant administered by Cancer Australia)

(2015 2018) National Breast Cancer Foundation

Expression of MAGE A and NY ESO 1 cancer testis antigens is enriched in triple negative invasive breast cancers

Raghavendra, Ashwini, Kalita de Croft, Priyakshi, Vargas, Ana Cristina, Smart, Chanel E., Simpson, Peter T., Saunus, Jodi M. and Lakhani, Sunil R. (2018) Expression of MAGE A and NY ESO 1 cancer testis antigens is enriched in triple negative invasive breast cancers.

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix Trench, Georgia, Al Ejeh, Fares and Lakhani, Sunil R. (2017) Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
original dr martens Dr Peter Simpson